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Deep Unsupervised Anomaly Detection in Brain Imaging: Large-Scale Benchmarking and Bias Analysis

Frotscher, Alexander, Baumgartner, Christian F., Wolfers, Thomas

arXiv.org Artificial Intelligence

Deep unsupervised anomaly detection in brain magnetic resonance imaging offers a promising route to identify pathological deviations without requiring lesion-specific annotations. Yet, fragmented evaluations, heterogeneous datasets, and inconsistent metrics have hindered progress toward clinical translation. Here, we present a large-scale, multi-center benchmark of deep unsupervised anomaly detection for brain imaging. The training cohort comprised 2,976 T1 and 2,972 T2-weighted scans from healthy individuals across six scanners, with ages ranging from 6 to 89 years. Validation used 92 scans to tune hyperparameters and estimate unbiased thresholds. Testing encompassed 2,221 T1w and 1,262 T2w scans spanning healthy datasets and diverse clinical cohorts. Across all algorithms, the Dice-based segmentation performance varied between 0.03 and 0.65, indicating substantial variability. To assess robustness, we systematically evaluated the impact of different scanners, lesion types and sizes, as well as demographics (age, sex). Reconstruction-based methods, particularly diffusion-inspired approaches, achieved the strongest lesion segmentation performance, while feature-based methods showed greater robustness under distributional shifts. However, systematic biases, such as scanner-related effects, were observed for the majority of algorithms, including that small and low-contrast lesions were missed more often, and that false positives varied with age and sex. Increasing healthy training data yields only modest gains, underscoring that current unsupervised anomaly detection frameworks are limited algorithmically rather than by data availability. Our benchmark establishes a transparent foundation for future research and highlights priorities for clinical translation, including image native pretraining, principled deviation measures, fairness-aware modeling, and robust domain adaptation.


Model Parallelism With Subnetwork Data Parallelism

Singh, Vaibhav, Khalid, Zafir, Oyallon, Edouard, Belilovsky, Eugene

arXiv.org Artificial Intelligence

Pre-training large neural networks at scale imposes heavy memory demands on accelerators and often requires costly communication. We introduce Subnetwork Data Parallelism (SDP), a distributed training framework that partitions a model into structured subnetworks trained across workers without exchanging activations. We study two complementary masking regimes: backward masking, which applies sparsity only in the backward step to retain unbiased gradients, and forward masking, which also removes parameters in the forward pass to deliver stronger efficiency gains while providing additional regularization. We further explore two subnetwork construction strategies: neuron level and block level, applied across both CNNs and transformers. In experiments spanning CNNs and transformers on CIFAR and ImageNet, as well as LLM pre-training on FineWeb, SDP reduces per-device memory usage by 30%-75% while maintaining or improving performance. Notably, in FLOP-matched settings, forward masking can sometimes achieve better performance.


Personalized and Demand-Based Education Concept: Practical Tools for Control Engineers

Varga, Balint, Fischer, Lars, Kovacs, Levente

arXiv.org Artificial Intelligence

This paper presents a personalized lecture concept using educational blocks and its demonstrative application in a new university lecture. Higher education faces daily challenges: deep and specialized knowledge is available from everywhere and accessible to almost everyone. University lecturers of specialized master courses confront the problem that their lectures are either too boring or too complex for the attending students. Additionally, curricula are changing more rapidly than they have in the past 10-30 years. The German education system comprises different educational forms, with universities providing less practical content. Consequently, many university students do not obtain the practical skills they should ideally gain through university lectures. Therefore, in this work, a new lecture concept is proposed based on the extension of the just-in-time teaching paradigm: Personalized and Demand-Based Education. This concept includes: 1) an initial assessment of students' backgrounds, 2) selecting the appropriate educational blocks, and 3) collecting ongoing feedback during the semester. The feedback was gathered via Pingo, ensuring anonymity for the students. Our concept was exemplarily tested in the new lecture "Practical Tools for Control Engineers" at the Karlsruhe Institute of Technology. The initial results indicate that our proposed concept could be beneficial in addressing the current challenges in higher education.


Seeing Beyond Frames: Zero-Shot Pedestrian Intention Prediction with Raw Temporal Video and Multimodal Cues

Zambare, Pallavi, Thanikella, Venkata Nikhil, Liu, Ying

arXiv.org Artificial Intelligence

Pedestrian intention prediction is essential for autonomous driving in complex urban environments. Conventional approaches depend on supervised learning over frame sequences and require extensive retraining to adapt to new scenarios. Here, we introduce BF-PIP (Beyond Frames Pedestrian Intention Prediction), a zero-shot approach built upon Gemini 2.5 Pro. It infers crossing intentions directly from short, continuous video clips enriched with structured JAAD metadata. In contrast to GPT-4V based methods that operate on discrete frames, BF-PIP processes uninterrupted temporal clips. It also incorporates bounding-box annotations and ego-vehicle speed via specialized multimodal prompts. Without any additional training, BF-PIP achieves 73% prediction accuracy, outperforming a GPT-4V baseline by 18 %. These findings illustrate that combining temporal video inputs with contextual cues enhances spatiotemporal perception and improves intent inference under ambiguous conditions. This approach paves the way for agile, retraining-free perception module in intelligent transportation system.


Evaluating the Goal-Directedness of Large Language Models

Everitt, Tom, Garbacea, Cristina, Bellot, Alexis, Richens, Jonathan, Papadatos, Henry, Campos, Siméon, Shah, Rohin

arXiv.org Artificial Intelligence

To what extent do LLMs use their capabilities towards their given goal? We take this as a measure of their goal-directedness. We evaluate goal-directedness on tasks that require information gathering, cognitive effort, and plan execution, where we use subtasks to infer each model's relevant capabilities. Our evaluations of LLMs from Google DeepMind, OpenAI, and Anthropic show that goal-directedness is relatively consistent across tasks, differs from task performance, and is only moderately sensitive to motivational prompts. Notably, most models are not fully goal-directed. We hope our goal-directedness evaluations will enable better monitoring of LLM progress, and enable more deliberate design choices of agentic properties in LLMs.


Accelerating Task Generalisation with Multi-Level Hierarchical Options

Cannon, Thomas P, Simsek, Özgür

arXiv.org Artificial Intelligence

Creating reinforcement learning agents that generalise effectively to new tasks is a key challenge in AI research. This paper introduces Fracture Cluster Options (FraCOs), a multi-level hierarchical reinforcement learning method that achieves state-of-the-art performance on difficult generalisation tasks. FraCOs identifies patterns in agent behaviour and forms options based on the expected future usefulness of those patterns, enabling rapid adaptation to new tasks. In tabular settings, FraCOs demonstrates effective transfer and improves performance as it grows in hierarchical depth. We evaluate FraCOs against state-of-the-art deep reinforcement learning algorithms in several complex procedurally generated environments. Our results show that FraCOs achieves higher in-distribution and out-of-distribution performance than competitors.


Lambda-Skip Connections: the architectural component that prevents Rank Collapse

Joseph, Federico Arangath, Sieber, Jerome, Zeilinger, Melanie N., Alonso, Carmen Amo

arXiv.org Machine Learning

Rank collapse, a phenomenon where embedding vectors in sequence models rapidly converge to a uniform token or equilibrium state, has recently gained attention in the deep learning literature. This phenomenon leads to reduced expressivity and potential training instabilities due to vanishing gradients. Empirical evidence suggests that architectural components like skip connections, LayerNorm, and MultiLayer Perceptrons (MLPs) play critical roles in mitigating rank collapse. While this issue is well-documented for transformers, alternative sequence models, such as State Space Models (SSMs), which have recently gained prominence, have not been thoroughly examined for similar vulnerabilities. This paper extends the theory of rank collapse from transformers to SSMs using a unifying framework that captures both architectures. We study how a parametrized version of the classic skip connection component, which we call \emph{lambda-skip connections}, provides guarantees for rank collapse prevention. Through analytical results, we present a sufficient condition to guarantee prevention of rank collapse across all the aforementioned architectures. We also study the necessity of this condition via ablation studies and analytical examples. To our knowledge, this is the first study that provides a general guarantee to prevent rank collapse, and that investigates rank collapse in the context of SSMs, offering valuable understanding for both theoreticians and practitioners. Finally, we validate our findings with experiments demonstrating the crucial role of architectural components such as skip connections and gating mechanisms in preventing rank collapse.


Learning Tree Pattern Transformations

Neider, Daniel, Sabellek, Leif, Schmidt, Johannes, Vehlken, Fabian, Zeume, Thomas

arXiv.org Artificial Intelligence

Explaining why and how a tree $t$ structurally differs from another tree $t^*$ is a question that is encountered throughout computer science, including in understanding tree-structured data such as XML or JSON data. In this article, we explore how to learn explanations for structural differences between pairs of trees from sample data: suppose we are given a set $\{(t_1, t_1^*),\dots, (t_n, t_n^*)\}$ of pairs of labelled, ordered trees; is there a small set of rules that explains the structural differences between all pairs $(t_i, t_i^*)$? This raises two research questions: (i) what is a good notion of "rule" in this context?; and (ii) how can sets of rules explaining a data set be learnt algorithmically? We explore these questions from the perspective of database theory by (1) introducing a pattern-based specification language for tree transformations; (2) exploring the computational complexity of variants of the above algorithmic problem, e.g. showing NP-hardness for very restricted variants; and (3) discussing how to solve the problem for data from CS education research using SAT solvers.


Moshi: a speech-text foundation model for real-time dialogue

Défossez, Alexandre, Mazaré, Laurent, Orsini, Manu, Royer, Amélie, Pérez, Patrick, Jégou, Hervé, Grave, Edouard, Zeghidour, Neil

arXiv.org Artificial Intelligence

We introduce Moshi, a speech-text foundation model and full-duplex spoken dialogue framework. Current systems for spoken dialogue rely on pipelines of independent components, namely voice activity detection, speech recognition, textual dialogue and text-to-speech. Such frameworks cannot emulate the experience of real conversations. First, their complexity induces a latency of several seconds between interactions. Second, text being the intermediate modality for dialogue, non-linguistic information that modifies meaning -- such as emotion or non-speech sounds -- is lost in the interaction. Finally, they rely on a segmentation into speaker turns, which does not take into account overlapping speech, interruptions and interjections. Moshi solves these independent issues altogether by casting spoken dialogue as speech-to-speech generation. Starting from a text language model backbone, Moshi generates speech as tokens from the residual quantizer of a neural audio codec, while modeling separately its own speech and that of the user into parallel streams. This allows for the removal of explicit speaker turns, and the modeling of arbitrary conversational dynamics. We moreover extend the hierarchical semantic-to-acoustic token generation of previous work to first predict time-aligned text tokens as a prefix to audio tokens. Not only this "Inner Monologue" method significantly improves the linguistic quality of generated speech, but we also illustrate how it can provide streaming speech recognition and text-to-speech. Our resulting model is the first real-time full-duplex spoken large language model, with a theoretical latency of 160ms, 200ms in practice, and is available at https://github.com/kyutai-labs/moshi.


Pard: Permutation-Invariant Autoregressive Diffusion for Graph Generation

Zhao, Lingxiao, Ding, Xueying, Akoglu, Leman

arXiv.org Artificial Intelligence

Graph generation has been dominated by autoregressive models due to their simplicity and effectiveness, despite their sensitivity to ordering. Yet diffusion models have garnered increasing attention, as they offer comparable performance while being permutation-invariant. Current graph diffusion models generate graphs in a one-shot fashion, but they require extra features and thousands of denoising steps to achieve optimal performance. We introduce PARD, a Permutation-invariant Auto Regressive Diffusion model that integrates diffusion models with autoregressive methods. PARD harnesses the effectiveness and efficiency of the autoregressive model while maintaining permutation invariance without ordering sensitivity. Specifically, we show that contrary to sets, elements in a graph are not entirely unordered and there is a unique partial order for nodes and edges. With this partial order, PARD generates a graph in a block-by-block, autoregressive fashion, where each block's probability is conditionally modeled by a shared diffusion model with an equivariant network. To ensure efficiency while being expressive, we further propose a higher-order graph transformer, which integrates transformer with PPGN. Like GPT, we extend the higher-order graph transformer to support parallel training of all blocks. Without any extra features, PARD achieves state-of-the-art performance on molecular and non-molecular datasets, and scales to large datasets like MOSES containing 1.9M molecules.